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It depends on what type of NAS you are using. NAS mount points can be presented via standard Unix or Windows servers. The underlying file system is the OS native file system (UFS, NTFS). You can use standard OS-based defrag to defragment the underlying file system. If you are using an appliance-based NAS solution (MAXXAN, NetApp, etc.), then you would use the utilities that are available with that solution.
You can back up NAS mount points with NDMP backup, or back up the underlying LUNS via a standard backup utility.
For more information, read expert Randy Kerns' advice on how to defrag a hard drive.
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