The only partition size issue I know of is the 4GB boot partition issue when doing an NT install onto SAN based disks from a floppy NT install. NTFS version 5 should easily handle any partition size you throw at it. Cluster resources can have issues on some vendor's subsystems when using partitions instead of full device LUNs to the reserve/release SCSI commands effecting resources when sharing the same physical devices on different partitions. This is especially true for load-balanced devices using HBA filter drivers (path failover software on the host).
I would check with your EMC rep for certified configurations when using Microsoft clustering.
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This was first published in June 2002