I don't know of any specific problems but I did find some information on that Microsoft support database that might be relevant:
Distributed File System (DFS) Home Directory Prevents Other DFS Connections (Q172330) - this error is regarding home directories with leafs on the same server. Only SMB (CIFS) semantics are supported and not DFS. This may be a problem for what you're trying to do.
In addition, I'm not sure that there isn't a conflict with Active Directory in this area. Since I haven't done this and don't know anyone who has, I recommend that you send an e-mail to Microsoft support (go through their Web site) and specifically ask them if there are any issues.
Evaluator Group, Inc.
Editor's note: Do you agree with this expert's response? If you have more to share, post it in our Storage Networking discussion forum.
Dig deeper on NAS management
Related Q&A from Randy Kerns
Learn why data protection practices common in traditional file storage environments aren't the best option for objects, and how metadata can help.continue reading
Learn how different scale-out architectures can be good options for providing high availability and easy growth.continue reading
Learn about NAS security and if SAN is more secure than NAS in this expert response.continue reading
Have a question for an expert?
Please add a title for your question
Get answers from a TechTarget expert on whatever's puzzling you.